CH-2026-04-29Fmoc-Rink Amide Linker, also known as Knorr Linker, is a widely used linker molecule in solid-phase peptide synthesis (SPPS). It is designed to be attached to polymer supports (such as polystyrene or PEG resins) and enables the synthesis of peptides with a C-terminal amide (-CONH₂) upon cleavage.
The linker contains an Fmoc (9-fluorenylmethyloxycarbonyl) protecting group, which can be selectively removed under mild basic conditions (typically piperidine), allowing stepwise peptide chain elongation. The Rink Amide structure ensures acid-labile cleavage, usually using TFA (trifluoroacetic acid), to release the final peptide with high purity and yield.
