Capto™ Q ion exchange chromatography resin

  • Author: Vishy Singh
  • Deadline: 31 Dec 2025

Overview

Designed to meet the demands of modern, large-scale manufacturers Capto Q’s shorter processing times can reduce exposure of the target protein.

  • Strong anion exchanger for high-productivity capture and intermediate purification when high volume throughput is essential.
  • High dynamic binding capacity at high flow raises productivity.
  • High-volume throughput cuts process times.
  • Cost-effective processing with smaller unit operations.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Offers increased productivity

Capto Q is designed for capture and intermediate purification of proteins from large feed volumes. It is composed of a rigid, high-flow agarose matrix modified with dextran surface extenders and a strong quaternary ammonium (Q) anion exchanger. The combination of high-volume throughput and high dynamic binding capacity for Capto Q raises the productivity in industrial downstream processes.


Durable and stable

Capto Q withstands effective and rigorous cleaning-in-place (CIP) procedure and the chemical stability supports long resin lifetime.

Chromatography technique Ion Exchange Chromatography
BioProcess resin Yes
Certificate of Analysis Yes
Chemical stability Commonly used aqueous buffers, 1 M acetic acid, 1 M NaOH, 8 M urea, 6 M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Ion Exchanger Type Strong anion exchanger
Ionic Capacity 0.16-0.22 mmol Cl-/ml medium
Ligand Quaternary amine
Matrix Highly cross-linked agarose with dextran surface extender
Particle size, d50V ~90 μm
Pressure/Flow Specification 0.3 MPa at 700 cm/h, 1 m diameter column, 20 cm bed height
Storage 4 to 30°C, 20% Ethanol
pH stability, CIP 2–14
pH stability, operational 2–12